Bone Abstracts

Mechanosenstitive osteocytes in bone supress the local production of sclerostin in response to mechanical loading, to increase osteoblast differentiation and bone mass. In addition, sclerostin is secreted from osteocytes into the circulation. Serum sclerostin has been shown to correlate with osteoporosis and low bone mass, however there is limited evidence by which to determine whether serum sclerostin is acting either a biomark...

see P231....

Rationale: Mice deficient in osteocalcin show an impaired glucose tolerance, however, the exact mechanism involved have yet to be fully elucidated. We aimed to overexpress osteocalcin to determine its effect on glucose homeostasis and explore the signalling pathway involved. We wished to expand upon previous preliminary data suggesting that this pathway involve neuropeptide Y (NPY) signalling.Objective: To analyse the in vivo and in vitro</e...